I shot an arrow at whats-his-face in Majora's Mask 3D and he went kablooie.
I never finished the game, because the control scheme is complicated and frustrating for me, but I did start a high chaos run through Dishonored.
I had no choice, but I felt bad the entire time that I had to let Suzy beat up that little kid who admired her so much in Deltarune. I truly despise her as a character.
I deliberately killed off my rescue party in Maniac Mansion. Could never bring myself to kill Weird Ed's hamster. Unless you count accidentally pressing the wrong button on the stairway and nuking everyone within a five mile radius.