This may sound thick since it's coming from a righty, but I figured most lefties who have a history of playing videogames would want the Wiimote to be in their right hands so that the analog stick could be in their left. After all, that's how all other controllers worked.
Yeah, it might sound awkward having to make motions with the hand you're least dexterous with, but they aren't complicated motions; it's not like you're signing your name with a pen or anything.