No way! I'm also left-handed! As you stated, however, it should be nothing too terrible.
Rich environments, great voice acting, a protagonist with spunk, a plethora of interesting enemies and boss battles, and a well-deserved multiplayer mode on top will make Uprising one for the ages. I can't help but draw parallels between the soon to be released game and Star Fox as well as Zelda.
Also, I don't know if you are aware of this or if you already handled the business but if you click here and are a member of Club Nintendo, you have the opportunity to receive three AR cards free of charge.