So many moments, it's hard to pick. Most of them from Okami. And not over huge things, but just *tiny* control issues I had that drove me up the wall.
There were a few rooms, particularly in the last dungeon, where I'd have to go really, really high up into a room, with all these jumps and platforms and all that, and I could not, for the life of me, get it right for one day. I just had so much trouble with it I gave up. Then I went back the next day and pretty much got everything on the first try. -_-