I've got some on the lookout that seem interesting and I'll check them out when I can. I've heard a lot of good about the Shin Megami Tensei games, so I'm gonna see if I can't pick up one of them at some point. Also the new Luigi's Mansion looks cool.
But as for ones I'm dying to get, here's mine:
Pokemon Y. Because a new Pokemon game will always get my attention.
Bioshock Infinte. Because floating cities are awesome, and the whole colonial aesthetic is really cool too.
Donkey Kong Country Returns. Because MONKEY SMASH!!!