Team Fortress 3 seems like a long shot as well, and no word on Left 4 Dead 3 either, so I would have to say yes.
However, I would like to see a new 3D Metroid series instead. And since everyone is speaking of Nintendo games, I would also love to see a Star Fox reboot of some sorts. Paper Mario U would be nice to see as well, along with a new 3D Donkey Kong. I loved what they did with Donkey Kong 64, I'm just hoping they'll do something like that again one day. If only Rare never left. So much potential went out the door and into the hands of Microsoft. :/