Most recently? Mario Kart lol. Almost finished. 1st place. Yes. Blue shell. Noooo. Profanity everywhere. Quit.
There was also a time in Okami I ragequit. I was playing it on the Wii, so you had to rely on the motion controls to draw the appropriate lines. There's a part in the game where some old guy is dancing, and then he'll point to things and you have to circle whatever he's pointing to. My Wiimote just wasn't drawing perfect enough circles and the game kept failing me (or maybe I was just that bad lol, but it makes me feel better to blame the 'mote, ssshh). To make matters worse, every time I failed, the cutscene would play again in that there was no way to skip it. I think I did this for a good half an hour before I threw the controller on the couch and declared I was done with life.