I'm not one to "replay" games, rregarding main quests, however I will if that game offers a good source of replayability, however the Zelda series really lacks in this department. Even my favourite game in the series, Twilight Princess, I'veonly played through four times since my initial purchase in 2007. So there are a few games that I've never bothered to give a second run through, however if I were to pick one game it would be Skyward Sword.
For me this game just didn't offer enough differentiation from the main quest to actually warrant another playthrough, I played through the game quite casually, completed everything and it took me around 35 hours. The one thing that I think SS lacked in was exploration and it's largely linear quests and overworld sections make for a too familiar experience. However due to this game being one of the least enjoyable games, in my experience anyway, I don't think I'll give it another playthrough, not even the Hero Mode.