When Goku sacrifices himself near the end of the battle against Cell... That moment brought a tear to my eyes.
But the one that always gets me is when Ash leaves his Butterfree... It's so sad.... Made me cry as a child, makes me cry now...
Of course. I am easily absorbed into the worlds created by anime. When the main character experiences loss, I tend to feel the same way and then I cry it's as simple as that.