Oh the topic of non-RPG games with female protagonists, the one that springs first to most people's minds is Tomb Raider. I have to be honest, I really didn't like the majority of games in that franchise. They seemed poorly made. even for their times, and focused too much on Lara being sexy, even though I didn't exactly find her attractive. In either the original series or the first reboot. I found most of the games to be lazy, boring, and none of the characters, including Lara, were that deep or developed or interesting. The current reboot however, is something different. I found this Lara to be much more attractive, but they absolutely did not try to sexify her. And I liked that. The performance was gritty and realistic. And you could see the transformation into a normal girl into a badass happening over time. Much, much better than the old games. Though I understand longtime fans of the series consider that to be a heretical statement. Good thing I don't care.
And about meddling in games being made, to force a protagonist of a certain gender and/race/sexuality to satisfy ideological views, that I'm completely opposed to. You've got to respect artistic freedom. When it's a character they love, that they worked hard on, you know you're going to get their best work and their hardest effort put into making it awesome. But when you force them to change what they had in mind simply to suit the whims of people who won't even play the games anyway, you're going to have a resentful person trying to make work, a character they didn't even want. And you're inevitably going to be disappointed in the results. Things like this have to be planned from the beginning, not forced the other way part way through.
On a related note to both those topics, I am okay with the implied romance between Lara and Sam in the new Tomb Raider because it's a reboot with entirely new versions of the character along with entirely new characters that you can make how you want. I don't like it when you force it on an existing character where you make it look like another sexuality was something they decided on or were convinced to try out (Willow from Buffy the Vampire Slayer being a prime example). That I think just insults that demographic more than it helps. If you want to change an existing character's sexuality, do it on a reboot, not halfway in the middle.