My most anticipated game is Resident Evil 6. I love most of the series and own a nice chunk of it and I can't wait to play as both Leon and Chris and they bring back Sherry and have Wesker's son. I just can't wait for it.
Now I own Kid Icarus: Uprising, I would have to say my most anticipated upcoming game is Luigis Mansion 2 for 3DS. I loved the first game and being how the graphics were tested and developed for luigi's mansion 2 were created by playing a version of Luigis Mansion on 3DS. I just want to see Luigi get more loving in.
(Ignore this post for the competition being how I won last month. I just wanted to join in the conversation)
My most anticipated game for 2012 is probably a new Zelda game. I have come to really like the series since last year and I think it would be cool if nintendo made a new game for Wii. (Since i only have a wii out of the consoles, unless i win the 3ds haha )