My longest gaming session with one game would only be about 10 hours that I can recall, and that was playing Twilight Princess when I first got my Wii. I know for a fact that I have spent longer times playing other games with my nephew in the past, but we never really time those to see how long they last....

Lately I don't think I could go that long, though, as I've been getting ill a lot recently and so I've been taking really long naps all the time, and wouldn't be able to stay up that many hours.