It doesn't really change anything because it is an alternate timeline. They advertised it like it was going to be a prequel to BotW but it really isn't. Other games fit together, but Age of Calamity is the one that can be tossed out or added in and it actually makes no difference.
I mean, all the Zelda games take place in alternate timelines that don't affect each other. Age of Calamity at the very least is a drastic shift within its own timeline. Other Zelda games usually end with the status quo restored and no events ever directly referenced again. The games are disconnected enough and the timeline dubious enough that removing the events of one affects virtually nothing about the story in other entries.
Age of Calamity has no such soft ending that can be easily rewritten into status quo mode.
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