I remember thinking Ash and Misty were supposed to be together when I was a kid and later stopped watching the anime for a long time. I turned on my TV, years later, to see this.... May. I though, "Who is this girl and where is my Misty?" It just felt.. weird.
Why isn't Kyouhei, and Mei on this list, I'd vote for them. Anime wise, Ash, and Misty, they obviously like etch other, remember "Misty's special bait", Ash got really mad when it was taken.
ummm guys? ash and dawn is up there... but my favorite would be red and leaf. I dunno i think they are the best.(but i dont think nintendo was trying too hard to make love interests in pokemon other than brock and some other background characters,like,the few hundreds there are i mean)